- Timothée Chalamet Yule
- Leonardo DiCaprio Dr. Randall Mindy
- Jennifer Lawrence Kate Dibiasky
- Melanie Lynskey June Mindy
- Jonah Hill Jason Orlean
- Cate Blanchett Brie Evantee
- Meryl Streep Presidenta Janie Orlean
- Ron Perlman Coronel Ben Drask
- Mark Rylance Peter Isherwell
- Michael Chiklis Dan Pawketty
- Tyler Perry Jack Bremmer
- Paul Guilfoyle General Themes
- Himesh Patel Phillip
- Rob Morgan Dr. Clayton 'Teddy' Oglethorpe
- Robert Joy Congresista Tenant
- Tomer Sisley Adul Grelio
- Ariana Grande Riley Bina
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