- Katie Holmes April Burns
- Patricia Clarkson Joy Burns
- Oliver Platt Jim Burns
- Derek Luke Bobby
- Alison Pill Beth Burns
- Alice Drummond Grandma Dottie
- John Gallagher Jr. Timmy Burns
- Sean Hayes Wayne
- Sisqó Latrell
- Isiah Whitlock Jr. Eugene
- Adrian Martinez Man in Mohair Sweater
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