- Matt Damon Odysseus
- Tom Holland Telemachus
- Jon Bernthal Menelaus
- Anne Hathaway Penelope
- Robert Pattinson Antinous
- Charlize Theron Calypso
- Zendaya Athena
- Elliot Page
- Mia Goth Melantho
- Ryan Hurst
- Lupita Nyong'o Helena de Troya / Clytemnestra
- Samantha Morton Circe
- John Leguizamo Eumaeus
- Josh Stewart
- Corey Hawkins
- Himesh Patel Eurylochus
- Bill Irwin Polyphemus
- Will Yun Lee
- Elyes Gabel
- Maurice Compte
- Shiloh Fernandez
- Jovan Adepo
- Rafi Gavron
- Jimmy Gonzales Cepheus
