- Robert Downey Jr. Victor von Doom / Doctor Doom
- Pedro Pascal Reed Richards / Mister Fantastic
- Chris Hemsworth Thor
- Vanessa Kirby Sue Storm / Invisible Woman
- Anthony Mackie Sam Wilson / Capitán America
- Sebastian Stan Bucky Barnes / Winter Soldier
- Ebon Moss-Bachrach Ben Grimm / The Thing
- Simu Liu Shang-Chi
- Florence Pugh Yelena Belova
- Lewis Pullman Robert Reynolds / Sentry
- Tom Hiddleston Loki
- Patrick Stewart Profesor Charles Xavier / Professor X
- Rebecca Romijn Raven Darkhölme / Mystique
- Alan Cumming Kurt Wagner / Nightcrawler
- Chris Evans Steve Rogers / Capitán America
- Kelsey Grammer Hank McCoy / Beast
- David Harbour Alexei Shostakov / Red Guardian
- Tenoch Huerta Namor
- Hannah John-Kamen Ava Starr / Ghost
- James Marsden Scott Summers / Cyclops
- Ian McKellen Erik Lehnsherr / Magneto
- Kathryn Newton Cassie Lang
- Joseph Quinn Johnny Storm / Human Torch
- Danny Ramirez Joaquin Torres / Falcon
- Paul Rudd Scott Lang / Ant-Man
- Wyatt Russell John Walker / U.S. Agent
- Remy LeBeau / Gambit Remy LeBeau / Gambit
- Letitia Wright Shuri / Black Panther
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