- Glenn Close Maggie
- Holly Hunter Sonia
- Kathy Baker Camille
- Elpidia Carrillo Sandra
- Amy Brenneman Lorna
- Stephen Dillane Martin
- Dakota Fanning Maria
- LisaGay Hamilton Holly
- Jason Isaacs Damian
- Amanda Seyfried Samantha
- Sissy Spacek Ruth
- Robin Wright Diana
- William Fichtner Andrew
- Joe Mantegna Richard
- Ian McShane Larry
- Molly Parker Lisa
- Mary Kay Place Alma Morgan
- Aidan Quinn Henry
- Chelsea Rendon Hija de Sandra
- Miguel Sandoval Ron
- Sydney Tamiia Poitier Vanessa
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