- George Clooney Fred Friendly
- David Strathairn Edward R. Murrow
- Patricia Clarkson Shirley Wershba
- Robert Downey Jr. Joe Wershba
- Jeff Daniels Sigfried “Sig” Mickelson
- Tate Donovan Jesse Zousmer
- Ray Wise Don Hollenbeck
- Frank Langella William Paley
- Robert John Burke Charlie Mack
- Reed Diamond John Aaron
- Thomas McCarthy Palmer Williams
- Matt Ross Eddie Scott
- Grant Heslov Don Hewitt
- Glenn Morshower Coronel Anderson
- Simon Helberg CBS Page
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