- Adewale Akinnuoye-Agbaje Heavy Duty
- Christopher Eccleston McCullen / Destro
- Joseph Gordon-Levitt El Doctor / Rex
- Lee Byung-Hun Storm Shadow
- Sienna Miller La Baronesa / Ana
- Rachel Nichols Scarlett
- Ray Park Snake Eyes
- Jonathan Pryce El Presidente
- Saïd Taghmaoui Breaker
- Channing Tatum Duke
- Marlon Wayans Ripcord
- Dennis Quaid General Hawk
- Arnold Vosloo Zartan
- David Murray McCullen 1641
- Karolina Kurkova Courtney A. Kreiger
