- Sam Worthington Perseo
- Gemma Arterton Io
- Mads Mikkelsen Draco
- Alexa Davalos Andrómeda
- Jason Flemyng Calibos / rey Acrisio
- Ralph Fiennes Hades
- Liam Neeson Zeus
- Danny Huston Poseidón
- Nicholas Hoult Eusabios
- Danny Huston Poseidon
- Tamer Hassan Ares
- Pete Postlethwaite Spyros
- Vincent Regan Kepheus
- Hans Matheson Ixas
- Liam Cunningham Solon
- Martin McCann Pheadrus
- Jamie Sives Commander
- Luke Evans Apollo
- Polly Walker Cassiopeia
- Luke Treadaway Prokopion
- Kaya Scodelario Peshet
- Izabella Miko Athena
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