- Aaron Eckhart Josh Keyes
- Hilary Swank Mayor Rebecca Childs
- Delroy Lindo Dr. Edward Brazleton
- Stanley Tucci Dr. Conrad Zimsky
- DJ Qualls Rata
- Tcheky Karyo Sergei Leveque
- Bruce Greenwood Comandante Robert Iverson
- Richard Jenkins General Thomas Purcell
- Alfre Woodard Stick
- Glenn Morshower Agente FBI
