- Owen Wilson Rick
- Jason Sudeikis Fred
- Jenna Fischer Maggie
- Christina Applegate Grace
- Nicky Whelan Leigh
- Richard Jenkins Coakley
- Stephen Merchant Gary
- Alexandra Daddario Paige
- Tyler Hoechlin Gerry
- Alyssa Milano Mandy
- Vanessa Angel Missy
- J.B. Smoove Flats
- Bo Burnham Bartender
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