- Marion Cotillard Dra. Leonora Orantes
- Matt Damon Thomas Emhoff
- Laurence Fishburne Dr. Ellis Cheever
- Jude Law Alan Krumwiede
- Gwyneth Paltrow Beth Emhoff
- Kate Winslet Dra. Erin Mears
- Josie Ho La hermana de Li Fai
- Bryan Cranston Haggerty
- John Hawkes
- Jennifer Ehle Dra. Ally Hextall
- Sanaa Lathan Aubrey Cheever
- Elliott Gould Dr. Ian Sussman
- Monique Gabriela Curnen Lorraine Vasquez
- Demetri Martin Dr. David Eisenberg
- Jillian Armenante
- Chin Han Sun Feng
- Armin Rohde Damian Leopold
- Tien You Chui Li Fai
- Daria Strokous Irina
- Amr Waked Rafik (sin acreditar)
- E. Roger Mitchell Conductor
