- Meryl Streep Violet Weston
- Julia Roberts Barbara Weston
- Ewan McGregor Bill Fordham
- Chris Cooper Charles Aiken
- Abigail Breslin Jean Fordham
- Benedict Cumberbatch 'Pequeño' Charles Aiken
- Juliette Lewis Karen Weston
- Margo Martindale Mattie Fae Aiken
- Dermot Mulroney Steve
- Julianne Nicholson Ivy Weston
- Sam Shepard Beverly Weston
- Misty Upham Johnna
- Newell Alexander Dr. Burke
