- Bradley Cooper Phil
- Ed Helms Stu
- Zach Galifianakis Alan
- Ken Jeong Mr. Chow
- Heather Graham Jade
- Justin Bartha Doug
- John Goodman Marshall
- Melissa McCarthy Cassie
- Jeffrey Tambor Sid
- Mike Epps Black Doug
- Sasha Barrese Tracy
- Jamie Chung Lauren
- Oliver Cooper Asistente de farmacia
