- Seth Rogen Mac Radner
- Zac Efron Teddy Sanders
- Rose Byrne Kelly Radner
- Christopher Mintz-Plasse Scoonie
- Dave Franco Pete
- Lisa Kudrow Carol Gladstone
- Ike Barinholtz Jimmy
- Jason Mantzoukas Dr. Theodorakis
- Jerrod Carmichael Garf
- Jake Johnson Sebastian Cremmington
- Halston Sage Brooke
- Anders Holm
- Hannibal Buress Officer Watkins
- Carla Gallo Paula
- Craig Roberts Assjuice
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