- Chadwick Boseman James Brown
- Nelsan Ellis Bobby Byrd
- Dan Aykroyd Ben Bart
- Viola Davis Susie Brown
- Craig Robinson Maceo Parker
- Octavia Spencer Tía Honey
- Lennie James Joe Brown
- Keith Robinson Baby Roy
- Fred Melamed Syd Nathan
- Brandon Smith Little Richard
- Aunjanue Ellis Vicki Anderson
- Jill Scott DeeDee Brown
- Tika Sumpter Yvonne Fair
- Aloe Blacc Nafloyd Scott
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