- Ben Affleck Nick Dunne
- Rosamund Pike Amy Dunne
- Neil Patrick Harris Desi Collings
- Tyler Perry Tanner Bolt
- Carrie Coon Margot Dunne
- Kim Dickens Detective Boney
- Patrick Fugit Detective Jim Gilpin
- Emily Ratajkowski Andie Hardy
- Missi Pyle Ellen Abbott
- Casey Wilson Noelle
- David Clennon Rand Elliot
- Boyd Holbrook Jeff
- Lola Kirke Greta
- Lisa Banes Marybeth Elliot
- Sela Ward Sharon Scheiber
- Scoot McNairy Tommy O'Hara
