- Will Smith Deadshot
- Jared Leto El Joker
- Margot Robbie Dra. Harleen Quinzel / Harley Quinn
- Joel Kinnaman Rick Flag
- Viola Davis Amanda Waller
- Jai Courtney Boomerang
- Jay Hernandez Diablo
- Adewale Akinnuoye-Agbaje Killer Croc
- Ike Barinholtz Griggs
- Scott Eastwood Teniente GQ Edwards
- Cara Delevingne Dra. June Moone / Encantadora
- Adam Beach Slipknot
- Karen Fukuhara Katana
- David Harbour Dexter Tolliver
- Common Monster T
- Ezra Miller The Flash
- Ted Whittall Admiral Olsen
- Ben Affleck Bruce Wayne / Batman
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