- Liam Hemsworth Jake Morrison
- Jeff Goldblum David Levinson
- Bill Pullman Presidente Whitmore
- Maika Monroe Patricia Whitmore
- Travis Tope Charlie
- William Fichtner General Adams
- Charlotte Gainsbourg Dr. Catherine Marceaux
- Judd Hirsch Julius Levinson
- Jessie T. Usher Dylan Hiller
- Sela Ward Presidenta Landford
- Brent Spiner Dr. Brackish Okun
- Vivica A. Fox Jasmine Dubrow-Hiller
- Angelababy Rain
- Joey King Sam
- Garrett Wareing Bobby
- Ryan Cartwright Ryan Collins
- Gbenga Akinnagbe Agente Matthew Travis
- Chin Han Commander Jiang Lao
- Deobia Oparei Dikembe Umbutu
- Mckenna Grace Daisy
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