- Josh Brolin Eddie Mannix
- George Clooney Baird Whitlock
- Alden Ehrenreich Hobie Doyle
- Ralph Fiennes Laurence Lorenz
- Jonah Hill Joe Silverman
- Scarlett Johansson Deeanna Moran
- Frances McDormand C.C. Calhoun
- Tilda Swinton Thora Thacker / Thessaly Thacker
- Channing Tatum Burt Gurney
- Christopher Lambert Arne Slessum
- Heather Goldenhersh Natalie (secretary)
- Clancy Brown Communist Screenwriter
- Jillian Armenante Script Girl
- Fisher Stevens Communist Writer #1
- David Krumholtz Communist Writer #4
- Dolph Lundgren Submarine Commander
- Peter Jason Director
- Fred Melamed Fred
- Ian Blackman Cuddahy
- Natasha Bassett Gloria DeLamour
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