- Leonardo DiCaprio Rick Dalton
- Brad Pitt Cliff Booth
- Margot Robbie Sharon Tate
- Dakota Fanning Squeaky Fromme
- Al Pacino Marvin Shwarz
- Timothy Olyphant James Stacy
- Kurt Russell Randy
- Margaret Qualley Pussycat
- Luke Perry Wayne Maunder
- Damian Lewis Steve McQueen
- Emile Hirsch Jay Sebring
- Rumer Willis Joanna Pettet
- Bruce Dern George Spahn
- Scoot McNairy Business Bob Gilbert
- Clifton Collins Jr. Ernesto The Mexican Vaquero
- Lew Temple Land Pirate Lew
- Maurice Compte Land Pirate Mao
- Michael Madsen
- Zoë Bell
- Brenda Vaccaro
- Spencer Garrett
- Mikey Madison Sadie
- Austin Butler Tex Watson
- Sydney Sweeney Snake
- Damon Herriman Charlie
- Lena Dunham Gypsy
- Julia Butters Trudi Fraser
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