- Benicio Del Toro Moses Rosenthaler
- Adrien Brody Julian Cadazio
- Tilda Swinton J. K. L. Berensen
- Léa Seydoux Simone
- Frances McDormand Lucinda Krementz
- Timothée Chalamet Zeffirelli
- Jeffrey Wright Roebuck Wright
- Mathieu Amalric The Commissaire
- Bill Murray Arthur Howitzer Jr.
- Owen Wilson Herbsaint Sazerac
- Liev Schreiber Talk Show Host
- Elisabeth Moss Alumna
- Edward Norton The Chauffeur
- Willem Dafoe Albert the Abacus
- Lois Smith Upshur Clampette
- Saoirse Ronan First Showgirl
- Christoph Waltz Paul Duval
- Cécile de France Mrs. B
- Guillaume Gallienne Mr. B
- Jason Schwartzman Hermes Jones
- Tony Revolori Moses Rosenthaler (joven)
- Rupert Friend Drill-Sergeant
- Henry Winkler Tío Joe
- Bob Balaban Tío Nick
- Hippolyte Girardot Chou-fleur
- Anjelica Huston Narradora (voz)
- Fisher Stevens Legal Advisor
- Griffin Dunne Editor
- Alex Lawther Morisot
- Wallace Wolodarsky Cheery Writer
- Denis Ménochet
- Vincent Macaigne
- Benjamin Lavernhe
- Lyna Khoudri Juliette
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