- Margot Robbie Harley Quinn
- Idris Elba Bloodsport
- John Cena Peacemaker
- Joel Kinnaman Rick Flag
- Jai Courtney Captain Boomerang
- Peter Capaldi Thinker
- Alice Braga Sol Soria
- Pete Davidson Blackguard
- Joaquín Cosio General Mateo Suarez
- Juan Diego Botto Luna
- Storm Reid Tyla
- Nathan Fillion T.D.K.
- Sean Gunn Weasel
- Flula Borg Javelin
- Sylvester Stallone King Shark (voz)
- Viola Davis Amanda Waller
- Michael Rooker Savant
- Taika Waititi
- David Dastmalchian Polka-Dot Man
- Daniela Melchior
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