- Danielle Deadwyler Mamie Till-Mobley
- Whoopi Goldberg Alma Carthan
- Jalyn Hall Emmett Till
- John Douglas Thompson Moses Wright
- Sean Patrick Thomas Gene Mobley
- Jayme Lawson Myrlie Evers
- Tosin Cole Medgar Evers
- Frankie Faison John Carthan
- Haley Bennett Carolyn Bryant
- Roger Guenveur Smith Dr. Howard
- Jaylin Webb Willie Hemphill
