Spider-man 2Dirigida por Sam Raimi - Tobey Maguire Peter Parker / Spider-Man
- Kirsten Dunst Mary Jane Watson
- Alfred Molina Dr. Otto Octavius (Dr. Octopus)
- James Franco Harry Osborn
- Rosemary Harris Tía May
- J.K. Simmons J. Jonah Jameson
- Daniel Gillies John Jameson
- Vanessa Ferlito Louise
- Dylan Baker Dr. Curt Connors
- Donna Murphy Rosalie Octavius
- Elizabeth Banks Betty Brant
- Bruce Campbell Snooty Usher
- Bill Nunn Joseph 'Robbie' Robertson
- Peter Cincotti Pianista
- Stan Lee
- Aasif Mandvi Mr. Aziz
- Emily Deschanel Recepcionista
- Joel McHale Sr. Jacks
- Peter McRobbie OsCorp Representative
- Cindy Cheung