- Matt Damon Edward Wilson
- Angelina Jolie Margaret "Clover"
- Robert De Niro General Bill Sullivan
- Tammy Blanchard Laura
- Alec Baldwin Sam Murach
- Michael Gambon Dr. Fredericks
- Joe Pesci Joseph Palmi
- Billy Crudup Arch Cummings
- Eddie Redmayne Edward Wilson Jr.
- Keir Dullea Senador Russell
- Martina Gedeck Hanna Schiller
- William Hurt Philip Allen
- Timothy Hutton Thomas Wilson
- Lee Pace Richard Hayes
- John Sessions Valentin
- Oleg Stefan Ulises / Stas Siyanko
- John Turturro Ray Brocco
- Gabriel Macht John Russell, Jr.
- Robert Prescott Bonesman MC 1961
- Jason Butler Harner
- Christopher Evan Welch
- Liya Kebede Miriam
- Michael Arden Pinafore Actor
- Josh Pence Bonesman (sin acreditar)
- Mark Ivanir Valentin Mironov
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