- Will Ferrell Jack Wyatt / Darrin Stephens
- Nicole Kidman Isabel Bigelow / Samantha Stephens
- Shirley MacLaine Iris Smythson / Endora
- Michael Caine Nigel Bigelow
- Jason Schwartzman Ritchie
- Heather Burns Nina Johnson
- Steve Carell Tío Arthur
- Kristin Chenoweth Maria Kelly
- Jim Turner Larry
- Stephen Colbert Stu Robison
- David Alan Grier Jim Fields
- Wendi McLendon-Covey E! Anchor
- Richard Kind Abner Kravitz
- P.J. Byrne Escritor
- Annie Mumolo Bed, Bath and Beyond Shopper
- Molly Gordon Trick-or-Treater
- Katie Finneran Sheila Wyatt
