- Samuel L. Jackson Lorenzo Council
- Julianne Moore Brenda Martin
- Edie Falco Karen Collucci
- Ron Eldard Danny Martin
- William Forsythe Boyle
- Aunjanue Ellis-Taylor Felicia
- Anthony Mackie Billy Williams
- LaTanya Richardson Marie
- Philip Bosco Priest
- Peter Friedman Lt. Gold
- Aasif Mandvi Dr. Anil Chatterjee
- Danielle Carter Cassandra
- Colman Domingo
- Domenick Lombardozzi Leo Sullivan
- Clarke Peters Reverendo Longway
- Liza Colón-Zayas Bea
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