- Naomi Watts Rachel Keller
- Martin Henderson Noah
- Brian Cox Richard Morgan
- David Dorfman Aidan Keller
- Lindsay Frost Ruth
- Jane Alexander Dra. Grasnik
- Amber Tamblyn Katie
- Rachael Bella Becca
- Daveigh Chase Samara
- Shannon Cochran Anna Morgan
- Sandra Thigpen Profesora
- Sasha Barrese Adolescente 1
