- Jessica Alba Morley Clarkson
- Kathy Bates Susan
- Jessica Biel Kara Monahan
- Bradley Cooper Holden
- Eric Dane Sean Jackson
- Patrick Dempsey Dr. Harrison Copeland
- Hector Elizondo Edgar
- Jamie Foxx Kelvin Moore
- Jennifer Garner Julia Fitzpatrick
- Topher Grace Jason
- Anne Hathaway Liz
- Ashton Kutcher Reed Bennett
- Queen Latifah Paula Thomas
- Taylor Lautner Willy
- George Lopez Alphonso
- Shirley MacLaine Estelle
- Emma Roberts Grace
- Julia Roberts Kate Hazeltine
- Taylor Swift Felicia
- Carter Jenkins Alex
- Katherine LaNasa Pamela Copeland
- Kristen Schaal Ms. Gilroy
- Bonnie Aarons
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