- Meryl Streep Margaret Thatcher
- Jim Broadbent Denis Thatcher
- Alexandra Roach Margaret Thatcher (joven)
- Harry Lloyd Denis Thatcher (joven)
- Olivia Colman Carol Thatcher
- Anthony Head Geoffrey Howe
- Richard E. Grant Michael Heseltine
- Roger Allam Gordon Reece
- Julian Wadham Francis Pym
- Michael Pennington Michael Foot
- Phoebe Waller-Bridge Susie
- James Smith
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