- Liam Neeson Bill Marks
- Julianne Moore Jen Summers
- Michelle Dockery Nancy
- Lupita Nyong'o Gwen
- Nate Parker Zach White
- Scoot McNairy Tom Bowen
- Corey Stoll Austin
- Omar Metwally Dr. Fahim Nasir
- Linus Roache David McMillan
- Jason Butler Harner Kyle Rice
- Shea Whigham Agente Marenick
- Anson Mount Jack Hammond
- Bar Paly Iris Marianne
- Jon Abrahams David Norton
- Corey Hawkins Travis Mitchell
- O-T Fagbenle Jack Rabbitte (voz)
