- Ed Helms Rusty Griswold
- Christina Applegate Debbie Griswold
- Beverly D'Angelo Ellen Griswold
- Chris Hemsworth Stone Crandall
- Leslie Mann Audrey Griswold
- Steele Stebbins Kevin Griswold
- Skyler Gisondo James Griswold
- Chevy Chase Clark Griswold
- Charlie Day Chad
- Michael Peña New Mexico Cop
- Keegan-Michael Key Jack Peterson
- Regina Hall Nancy Peterson
- Samm Levine Festival Dude Sam
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