- Benedict Cumberbatch Dr. Stephen Strange
- Chiwetel Ejiofor Mordo
- Rachel McAdams Christine Palmer
- Benedict Wong Wong
- Mads Mikkelsen Kaecilius
- Tilda Swinton Ancient One
- Michael Stuhlbarg Nicodemus West
- Benjamin Bratt Jonathan Pangborn
- Scott Adkins Lucian / Strong Zealot
- Amy Landecker Dr. Bruner
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