- Gal Gadot Linnet Ridgeway Doyle
- Sophie Okonedo Salome Otterbourne
- Rose Leslie Louise
- Armie Hammer Simon Doyle
- Kenneth Branagh Hercule Poirot
- Annette Bening Euphemia
- Letitia Wright Rosalie Otterbourne
- Tom Bateman Bouc
- Jennifer Saunders Marie Van Schuyler
- Russell Brand Dr Bessner
- Adam Garcia Syd
- Dawn French Mrs Bowers
- Ali Fazal Andrew Katchadourian
- Emma Mackey Jacqueline de Bellefort
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