- Benedict Cumberbatch Louis Wain
- Claire Foy Emily Richardson-Wain
- Andrea Riseborough Caroline Wain
- Toby Jones Sir William Ingram
- Stacy Martin Felicie Wain
- Adeel Akhtar Dan Rider
- Sharon Rooney Josephine Wain
- Taika Waititi Max Kase
- Richard Ayoade Henry Wood
- Dorothy Atkinson Mrs. DuFrayne
- Olivia Colman Narradora
- Crystal Clarke Alicia Simmonds
- Aimee Lou Wood Claire Wain
- Olivier Richters
