- Tom Cruise Ethan Hunt
- Ving Rhames Luther Stickell
- Michelle Monaghan Julia
- Jonathan Rhys Meyers Declan
- Laurence Fishburne John Brassel
- Philip Seymour Hoffman Owen Davian
- Keri Russell Lindsey
- Billy Crudup Musgrave
- Maggie Q Zhen
- Eddie Marsan
- Simon Pegg Benji Dunn
- Sasha Alexander Melissa
- Aaron Paul Rick
- Paolo Bonacelli Monsignore
- Sean O'Bryan Party Goer
- Carla Gallo Beth
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