- Milla Jovovich Alice
- Michelle Rodriguez Rain Ocampo
- Sienna Guillory Jill Valentine
- Kevin Durand Barry Burton
- Oded Fehr Carlos Olivera
- Li Bingbing Ada Wong
- Johann Urb Leon Kennedy
- Shawn Roberts Albert Wesker
- Boris Kodjoe Luther West
- Aryana Engineer Becky
- Colin Salmon James "One" Shade
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