- Leonardo DiCaprio Billy
- Matt Damon Colin
- Mark Wahlberg Dignam
- Jack Nicholson Costello
- Ray Winstone Mr. French
- Vera Farmiga Madolyn
- Alec Baldwin Ellerby
- Martin Sheen Oliver Queenan
- Anthony Anderson Brown
- Kevin Corrigan Sean
- David O'Hara Fitzy
- Robert Wahlberg Lazio (FBI)
- Mark Rolston Delahunt
- James Badge Dale Barrigan
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