Spider-man 3Dirigida por Sam Raimi - Tobey Maguire Peter Parker / Spider-Man
- Kirsten Dunst Mary Jane Watson
- James Franco Harry Osborn
- Thomas Haden Church Flint Marko / Hombre de arena
- Topher Grace Eddie Brock / Venom
- Bryce Dallas Howard Gwen Stacy
- James Cromwell Capitán Stacy
- Rosemary Harris Tía May
- J.K. Simmons J. Jonah Jameson
- Dylan Baker Dr. Curt Connors
- Elizabeth Banks Betty Brant
- Adrian Lester Científico
- Anya Avaeva Modelo
- Bill Nunn Joseph Robbie Robertson
- Theresa Russell Sra. Marko
- Cliff Robertson Ben Parker
- Ted Raimi Hoffman
- Daniel Gillies John Jameson
- Reynaldo Gallegos
- Perla Haney-Jardine Penny Marko
- Stan Lee
- Lucy Gordon Jennifer Dugan
- Joe Manganiello Flash Thompson